Constitutively Active G Protein-coupled Receptor Mutants BlockDictyosteliumDevelopment
نویسندگان
چکیده
منابع مشابه
Constitutively active G protein-coupled receptor mutants block dictyostelium development.
cAR1, a G protein-coupled receptor (GPCR) for cAMP, is required for the multicellular development of Dictyostelium. The activation of multiple pathways by cAR1 is transient because of poorly defined adaptation mechanisms. To investigate this, we used a genetic screen for impaired development to isolate four dominant-negative cAR1 mutants, designated DN1-4. The mutant receptors inhibit multiple ...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2005
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.e04-06-0456